Lanefan
Victoria Rules
Losing a lot of wealth was often at stake in early D&D, in that if you failed a save vs area damage (fireball, lightning, etc.) all your items also had to save.Does being banished from their hometown count? Or having their beloved killed? Or losing all their wealth and fame? These are all long-lasting personal detrimental effects that are part and parcel of the sorts of stories (fantasy and others) that inspire RPGs. D&D, as typically played, rarely puts these at stake. But many other RPGs do.
3e cut way back on this and 4e-5e dropped it completely.
As for the other things - being banished from my hometown would likely be in response to something I willingly did in-character, which means I'd likely already be in a position to not care. Having my beloved killed gives me a two-headed story arc to follow: getting that person revived and exacting revenge on the killer(s). Losing fame? Well, of all the dozens of characters I've ever played I can only think of one who gave a flip about her own personal fame, though for that one character fame - and resulting political success - is a core part of her personality and long-term (non-adventuring) goals.