Cyronax
Explorer
Excellent clarification of what the OP probably meant.
If you take a trip to deepest darkest Africa to explore some lost tomb, you're probably going to be out of tough and gone for a while.
While not literally locked up in chains, the person is tied up with business and cannot simply alter course and jump back stateside right away.
Its like owning a house in a depressed housing market and you're mortgage is underwater.


On a slightly related note:
In my current sandboxy campaign, I've had a few possible opportunities for the PCs to set down roots in a base of operations of their own. I'm not sure if they ever follow up on that, given the other quests they've already seemed most interested in following (in-character), but it led me to start thinking hypothetically about how run sandbox adventures for a group that is more or less in stationary, fortified area. An area I might add is only about the size of the village.
So I started thinking about Birthright campaign style that incorporated Skill Challenges to simulate the passing of time with regards to situation reports about their locality, its upkeep, and any dangers or opportunities looming.
The skills Nature, Insight, and Streetwise would seem to be the best choices for this. Luckily most of the PCs are great at these skills, so they might do well in a encounters based around a fixed operations site.
C.I.D.