This is where knowing your players is key. Because a player could easily get squicked or upset with you if you tred too much into waters that could be personal.In my example of the women who are pregnant with abominations, this situation may fail to interest the players, because as I described it, it has no direct impact to the players. Make one of the pregnant women related to a PC (or one of the PCs), and now at least one player probably cares.
I had an NPC who went insane after a miscarriage. I thought this was an interesting and human explanation for her behavior rather than just "She's nuts". A female player got really upset with me because I brought it up.