Don't forget structural damage.
I would use high level spell analogues;
Instantaneous Sphere of Annihilation at ground zero (thousands of feet)
Radiant damage (sunburst?) 1st mile out
Firestorm next mile radius
...with lingering necrotic from ground zero to full radius...
There is plenty of info on the affects of such weapons, to give you an idea of the size.
However, in game terms [MENTION=19675]Dannyalcatraz[/MENTION] is correct, you can story/rp/handwave most of it.
Perhaps give some lingering necrotic that can't be cured and uses a disease track with a high DC to survive the stages and get better, if you want survivors to deal with the after affects.
I would use high level spell analogues;
Instantaneous Sphere of Annihilation at ground zero (thousands of feet)
Radiant damage (sunburst?) 1st mile out
Firestorm next mile radius
...with lingering necrotic from ground zero to full radius...
There is plenty of info on the affects of such weapons, to give you an idea of the size.
However, in game terms [MENTION=19675]Dannyalcatraz[/MENTION] is correct, you can story/rp/handwave most of it.
Perhaps give some lingering necrotic that can't be cured and uses a disease track with a high DC to survive the stages and get better, if you want survivors to deal with the after affects.