Some more food for thought to get people's creative juices going -- again, this might be similar to other systems or not.
PC have Physical, Mental, and Spiritual stats:
Physical........Mental.........Spiritual
------------..---------.....--------
Strength.......Intelligence..Charisma.........| Fortitude
Dexterity.......Perception...Sanity............| Reflex
Constitution...Wisdom.......Self-Discipline..| Will
==========.========...==========
Phys HP/Body.Mental HP/Mind.Spirit HP/Soul
The top row of stats are your power stats and affect your Fortitude. The middle stats are your Finesse stats and affect Reflex, and the bottom row stats are the resistance stats and affect Will.
Likewise, a PC's physical HP/Body is made from the physical stats (1st column), the PC's Mental HP/Mind is made from the Mental stats, and the PC's Soul/Spirit HP are made up from the Spiritual stats.
Having three sets of Body/Mind/Soul would allow different types of attacks and stuff. Physical/Melee is obviously Body. However, Domination and Mind Flayer type attacks could be attacking Mind Points, and perhaps, a warlock trying to summon a demon to control it would be battling with his Soul Points and trying to wear down the demons Soul points.
If we include in the Fatigue/Combat Points type idea, then one option would be to have a common Fatigue which gets worn down from attacks, using special skills, casting spells, channeling prayers, etc., and after that, the Body/Mind/or Soul stats start to get used up. Or, the second option is to have separate Physical Fatigue, Mental Fatigue, and Spiritual Fatigue. Physical skills/damage eat up Phy Fatigue, Spells and mental damage use up Mental, Praying and soul damage use up Spiritual Fatigue first.