Where I think the confusiin might lie is in other editions and games, and effect would not be delivered if ALL damage was negated by some resistance. EXAMPLE: a creature negates up to five points from edged weapons. They are struck by a poison blade. In other rules, if a blade did less than 5, it didn't poke through the tough skin, break through the force field, etc, and so the poison couldn't be delivered. I think even in 4e if a situation like that comes up I may use fiat+common sense