The Cat Plaque
After having survived the dangers, and negotiated the depths of the ruins, you find the long-lost Temple of Carbuncle, where the artifact is rumoured to be hidden, according to the Bard. Most of the place is in ruins, but on the end of the room opposite from the entrance, your torches send back gleams of ruby from the far wall!
Cautiously advancing, you see a dais a foot or so above the floor, and hanging on the wall above it is a plaque shaped like a horned cat's face, the religious symbol of Carbuncle, maker of the artifact that is supposed to stop the plague!
Drawing closer, you can see that the plaque looks like a blue cat's face, with a horn, twisted, contorted features, and open mouth with swollen lips. Inscribed upon it, in the Common tongue, is:
I protect the bane of plagues,
I'm gained by none who stand on legs.
Humility may bypass me,
But arrogance for burning begs.
ACTIONS?
The Cat-plaque conceals a sliding puzzle-lock (DC to be set by the GM, as appropriate to the PCs' levels), as well as a trap which will blast the 30' conical area in front of the plaque with disease-causing spores which will induce a burning fever in any character who steps upon the dais, as opposed to kneeling. Protection from/Endure Elements (Fire/Acid) will avail nothing.
Of course, if the PCs get past the plaque and gain the magical cure-all artifact, any diseased PCs can be cured. Remember, though, that if anyone stands while trying to solve the puzzle lock, Carbuncle will "breathe" on them!...