I'm not sure about the despair part, but some of the most emotional and beautiful music I've ever heard was by Enya especially May it Be on the LotR:FotR sound track.
You might also try Annie Lennox with her breath taking Into the West off the LotR:RotK sound track. Actually, you might as well look at all the LotR tracks. I find the music when Gandalf falls
in Moria particuarly heart-wrenching. Trust me, if your players are'nt cold-hearted assasins you could invoke just about any emotion you want from them with LotR soundtracks.
You might also try Annie Lennox with her breath taking Into the West off the LotR:RotK sound track. Actually, you might as well look at all the LotR tracks. I find the music when Gandalf falls
in Moria particuarly heart-wrenching. Trust me, if your players are'nt cold-hearted assasins you could invoke just about any emotion you want from them with LotR soundtracks.