Well I have been running a campaign in the Scarred Lands for the past 8 months.
IT was mostly located in Vesh although there were a few side trips to the Hornsaw Forest and Mithril. The game timeline was streteched over 5 years with many interesting things happening ni between.
At the end when I ended the campaign, Vesh was a mess of smaller city states who act as vassals to the corrupt state of Canceri to the east. Peace has still not come to the land with my group's heroes messing with my villains plans. One is now a leader of small feudal country bordering Canceri, another is part of the leadership who control Mithril who is remodelling the city in his image, curse his ego! One more is looking to meet his twin brother who is the main villain of the campaign and the last noe has gone into exile to atone for his sins in the Hornsaw.
Now as you can see I run a very twisted Scarred Lands campaign but hey, whatever works. The party's average level is 20+ with the Paragon template added in though the campaign started at 1st level.
Enjoy