JohnSnow
Hero
I have occasionally thought about taking the Shadowrun setting and putting together a campaign that I'd run using the SWADE rules (plus Fantasy and Sci-Fi companions). It's certainly flexible enough to run it, and one could tune up the lethality/maiming rules with relative ease.So, with some more survey results in from my players, my ideas of the leaders has changed somewhat.
Spirit of the Century - will mean I need to do more prep, but I expect my players would love the genre and high-action.
Deadlands: The Lost Colony - also stays on the list.
Shadowrun Anarchy - The genre here would be another favorite. But, I dunno if I can recommend the main rules line of any edition. These more narrative rules might open up the genre. I am trying them out separately next month anyway, so this is now on the list.
I haven't gotten around to running it yet, but if the concept appeals to you, feel free to borrow the idea.