I am pretty much good with anything, though I like a more light hearted playing environment (Example, friend of mine was playing a ranger, he rolled a 1 when trying to identify a beast another character described to him. He quizzically looked at them and said, "You say it had four legs?"). As far as systems go, I have played D&D 3.5, D20 Modern, DC Heros, and Vampire. I also like tinkering with rules and making my own.
My wife generally likes over the top fantasy settings. Character creation with her is usually an exercise in me explaining to her why she can't have a Griffon, Dragon, Nightmare, Pegasus, or some other Higher powered animal companion or mount at level one. She also is a big fan of lots of action, so political games with her... not so much, but save the world or pillage and destroy, she is happy with.
Are you looking for someone to run a game or play, or both?