Expanding on these with the new information we've put together in the past couple days:Achelb: Large city which relies primarily on Porters to move goods. Built in a mountain pass at the entry to a great green valley largely worked by slaves rather than citizens. Nearby small town also bears the name Achelb and is, essentially, a portertown, where people rest between trips to and from the city up rocky trails while carrying imports and exports.
Ellenici: Divided citystate scattered across many islands. Lots of tiny communities with a few cities. Most locales with more than a modest Town population consider themselves to be independent Kingdoms with their own rulers. Largely a mystery, but there are bigger cities to the north, where the mainland is. Strangely, they do not realize they are cursed.
Il'sha-ah: Egyptian region. A single major center of commerce along the Cobra river, with several large towns and a small city further south along the river, former capital, perhaps? Several cities in the desert that have succumbed to it, half-buried, with dunes rolling in, still. There are people within the region who actively seek to uncover the ruins in the hopes of learning what mortalkind did to earn the Wrath of the Gods.
Musarra: Sumerian/Babylonian region. Several small towns in the area, one large city and perhaps a small city as a rival for control over the region? Ziggurats and ruined former cities along rocky declines and near tainted oases. Some people travel from Il'sha-ah to study the ruins and try to find the cause of the curses.
I could use a few more regions... maybe a jungle to the East or West?

(Dungeons & Dragons)
Rulebook featuring "high magic" options, including a host of new spells.