It could be done though
The Smurfs would be tiny creatures with a hive mind, say level 1-3 commoners with 2 hitdice (Smurfs are tough)
Each Smurf would have 1 feat a stchick or 1 high stat at 14 the rest would be 8-12
Alignment Lawful something ll let you decide the other part
Gargamel would be either a Wizard or better Alchemist (from Swashbuckling Adventures) with a cat familiar
Papa Smurf is an Adept and Grand Pa Smurf has levels in an adventuring class
Easy and in a sick way kind of fun--- I get to play Gargamel "I'll get you wretchid Smurfs"
Anyone want to see Gargamel as a 3e more serious 3e character?