Other than normal DM tips, which I assume you're not looking for, my only 5E specific suggestion is to keep it simple. 5E is meant to run smoothly, with the rules supporting the action, rather than dictating it. Keep your check DCs fairly low (8-14), unless it's something that you want the PCs to likely fail (15+), and only call for a check when you feel it's needed (often it's best just to go without). Also, make sure you know how you're going to use Wisdom/Perception vs. Intelligence/Investigation (an often debated topic IME) so that its consistent for your players.