That's what I did with my Supers:1900 campaign, basically set in the world of Space:1889.
I didn't care too much about gods vs techie vs aliens vs mutants...I just wanted PCs who had turn of the century ideas, clothing and so forth. It worked out great, too: the gadgeteer was based off of James West (Wild, Wild, West TV show), and the strongman was (among other things) a balding, handlebar mustachioed, club wielding, leopardskin wearing bruiser. Even the sonic based PC was thematically on point, with a looooong name lifted from a floridly titled piece of classical music, "Sonata (something) in key of something)."
I didn't care too much about gods vs techie vs aliens vs mutants...I just wanted PCs who had turn of the century ideas, clothing and so forth. It worked out great, too: the gadgeteer was based off of James West (Wild, Wild, West TV show), and the strongman was (among other things) a balding, handlebar mustachioed, club wielding, leopardskin wearing bruiser. Even the sonic based PC was thematically on point, with a looooong name lifted from a floridly titled piece of classical music, "Sonata (something) in key of something)."