Cyberpunk would be an interesting route to take in my opinion.
The following is an opinion and is based on what has been gathered, not actual research; corrections may be needed...
Generally, the genre applies to a futuristic setting with high technology replacing a lot of the more common magic and gear of a typical D&D setting. Mechanical augmentations, hormone enhancing injections (think short term steroids), computer coding being used in espionage and other sorts of hacking, and as has been mentioned, often an overarching company or group of companies seeking power or control over the world at large are staples of it. It tends to be a bit more gritty than classical D&D, with the lines of morality and ethics being more subjective than absolute, leaning toward more blurred senses of what is(/isn't/can be/etc..) right. Extraterrestrial influence exists in some sources, is absent in others, and is questionable in others still. Often there is some degree of off-planetary travel, including space-station bases and things of that sort.
I believe the better known sources would be movies like Bladerunner, Akira, and Armitage (there are others but those three come to mind), and television shows like Aeon Flux (from MTV a few years back) and others that I can't think of right now.
It would be an interesting route to take, but it's definitely a sort of cult-genre with a devoted following of people who really get into it, and an equal-sized group that doesn't. I'd be interested in pursuing cyberpunk as an idea for it, but it would take some dedicated players to fully flesh it out to do the concept properly.