I recently had an vampiric villain get staked. Not completely unexpected.
The PCs had encountered her a few times and had just foiled her plan to mind control the Lord Mayor. Somewhat to my surprise they then decided she had to die. This struck me as odd as she herself hadn't done anything more heinous than dodgy urban renewal in a poor neighbourhood. But PCs gonna murder.
Killing her took some effort, she "lived" in a mansion with high security. But they managed to pull it off and staked her in her coffin.
My vamp's name was Theresa Polidori. Seems we have similar inspirations for our vampires,
@TravDoc42.