Olaf the Stout said:
Thanks for the links Merric. If I added Ticket to Ride to the list of choices would you pick that over the other games?
In this instance (a game you can play with your wife): Yes. It's a really inspired game, and very obvious as to how it works - which I consider important in this instance.
Ticket to Ride: Europe -
http://www.boardgamegeek.com/game/14996
At the beginning of the game, you get a number of tickets: each lists two stations that you have to connect together.
During the game, you pick up cards in a number of colours (white, black, yellow, red, wild, etc.) When you have enough of a single colour, you play them to claim a route of the same colour. (Some routes can be taken by any colour). To connect the stations on your tickets, you may need 2, 3, 4, 5 or even more routes.
You score points whenever you claim a route (the longer routes are worth more), and place markers on the route to show that it's yours. When someone runs out of markers (trains), the game ends.
Players then get bonus points for each ticket they completed, and lose points for each ticket left uncompleted. Whoever has the most points wins!
TTR: Europe is more friendly than the other variants primarily because of Stations, which allow you to use a route someone else placed (instead of being blocked and being forced to lose points).

<-- click here!
A Game Turn:
Do
one of the following:
* Pick up 2 colour cards from the 5 available (they're replaced as they're taken)
* Claim a route by playing a set of matching colour cards (a route that is 4 long requires 4 cards)
* Draw 3 new ticket cards, and keep at least 1.
* Play a station (by discarding a set of 1-3 colour cards).
Cheers!