Man, I'd love to see what kind of games are being made in Spain right now. I would give my right eye to play a game set in Sevilla during the Siglo de Oro, or something about the Reconquista.
Then
Aquelarre would be for you. It's a d100-based game set in Spain, which covers two periods (as in the latter editions of CoC): the 14th and the 17th Centuries. It's "catch" is the assumption that local folklore and myths were real, and they can affect you more the more you believe in them. If you can read Spanish, there should be a free pdf preview from one of the latest editions. It's currently out of print, but there might be a new edition from the Spanish publishers of Mutants & Masterminds.
EXO is a generic sci-fi game, mainly focused on "hard" sci-fi, but with space for more flashy things, and it has been fairly successful (the 2nd Edition has just been published - and we didn't even have edition wars!

). The same publisher has other games as
Comandos de Guerra (a game about WWII),
Rol Negro (Noir with a mix of GTA/Sin City) and
Pangea (Prehistoric fantasy).
And, talking about Spanish games,
Mutantes en la sombra must be mentioned. It was published almost 20 years ago, and went out of print during the mid 90's, but it was huge back then. Funny story is, its plot is basically the same as the tv series Heroes.
There was yet another one worth mentioning:
Fanhunter. It was based on a fairly successful comic book of the same name. Its setting is a cyberpunk/slapstick comedy where a mad bookseller took over the world and forbade every expression of subculture, as comics, rpgs, sci-fi, movies or even soccer, and the players are part of the resistance. Its system was a rip-off from Ghostbusters, but it was fun as hell

. It even had a skirmish miniatures game (which was itself a rip-off from Space Hulk

). Sadly, it's out of print, too.
There were and are some others (and now we have a new bunch of them thanks to pdf and lulu.com, mainly Fudge-based), but these ones are, IMO, the best.