I imagine Streetwise be similar to Streetwise in WoD. So good for urban, illegal stuff and that sort, and knowing urban connections, as well as being knowledgeable on how to track in a city or disappear in a city, etc. Essentially Urban version of Nature.
WoD Streetwise: "Characters possessing this Skill know how life on the streets works and are adept at surviving by its harsh rules. Streetwise characters can gather information, make contacts, buy and sell on the black market, and otherwise make use of the street's unique resources. The Skill is also important for navigating urban dangers, avoiding the law, and staying on the right side of the wrong people."