I miss Vampire. I have every intention of playing / running it again, especially with the new rules, but it just never seems to come together - one of the issues is prep time. I just don't have any these days, so I can't write up a full city of new vamps to play with.
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I REALLY miss CyberPunk. Except, well, that I have lost much of my love for the system itself. Unlike the other people who I was working with on the CyberPunk 2 to CyberPunk 3 bridge products (which tanked... sigh), I'm just not a fan of the system anymore. To make matters worse, I *am* a fan of Humanity Loss and CyberPsychosis, which are dying breeds.
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I miss Twilight 2000 (original edition). It makes a great PBEM game, with lots of number crunching. I just love it.
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Top Secret (original edition, not S.I.). My gamers hate it. I love it. A system where it is assumed you have the skills to be a spy, so everything is run by stats. The only thing better, IMO, is the original system from Haven: City of Violence, which is a cleaned up version of TS (with the serial numbers BARELY filed off). I have run Operation: Sprechenhaltestelle (codename: Pisces) several times in different systems - Star Frontiers, d20 Modern, CyberPunk.
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Villains & Vigilantes - I keep pulling this back out, dusting it off, and then putting it back away. I think my players would even enjoy it... but I just can't swing supers anymore.
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MegaTraveller - this is by far my fave edition of Traveller. Just don't have the time to resurrect it, however.
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Street Fighter - Awesome use of the StoryTeller system. I actually ran a campaign of this while unemployed a few years ago, with both my daughters as the players.
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Gamma World - I love the third edition (the red-headed stepchild edition, the one that used the colored chart resolution system, and by far the BEST implementation of that resolution system that TSR tried to pry into every RPG they released except D&D). In fact, I ran Omega World last summer and it was a RIOT.
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I would have added Star Frontiers to this list, but I'm running it again.