With one exception, none of the following are hard "no's", if a friend insisted and had an easier onramp, I'd probably give it a go.
Pokémon. I was a little too old when this started to get popular and missed it, and have little desire to dig into the list of various Pokémon and trainers and such.
With that, TCGs outside of MTG. Magic eats enough of my income, I'm glad Lorcana, Pokémon, YuGiOh and the others are around, but I'm not looking for another form of cardboard crack.
MMOs. I've tried. WoW, STO, SW: the Old Republic, a bunch others when I dated someone that was a big MMO guy ... these just aren't for me. I tend to be ... antisocial when it comes to videogame RPGs, so I'll enjoy my single player Mass Effects and Baldur's Gates and not delve into multi-player (though BG3 almost got me).
And finally, the exception is Harry Potter. There is no ethical way I can justify buying any of it any further while profits are used to support political oppression. I won't destroy or sell off what I already own, but that door is now locked. No more.