Only if the rules are complex and expensive. If the rules are simple and free, or inexpensive, the barrier comes down to the sunk-cost fallacy.
But then, by definition, it's not a new rule set. It's not really that much of a new game. It's 5E modern, or 5E with spaceships, or 5E with spies. It's taking a not that great fantasy rules set and mangling it to fit genres it wasn't designed to handle. It's terrible design, generally speaking.
If you mean generally, then yes. But then most RPGs have a similar language. Turn, round, dice, hit points, GM, player, PC, NPC, etc. If you mean language in the sense of using the 5E rules, then no. Because that's not actually pivoting at all.
That assumes that 5E can handle every genre, style, and tone with a little tweaking. That's not true. It can't be all things to all people.