I know I'm going a little outside the time constraints of the thread, but...
WOTC: XPH, Savage Species, 3Ed/3.5 Ed
Malhavoc: Arcana Unearthed
Green Ronin: Book of the Righteous. I don't care about the pantheons so much as the appendix for generating Holy Warriors. Mutants & Masterminds.
WizKids: Pirates of the Spanish Main/Rocketmen: Axis of Evil.
HEROgames: HERO 5Ed.
Atlas Games: Nyambe, Northern Crown
AEG: Swashbucking Adventures, Spycraft
Pinnacle: Deadlands
Some older games I thought broke new ground: M:TG, Traveller, RoboRally, Space 1889, Crimson Skies, Iron Dragon, Car Wars, ShadowRun, Paranoia, Call of Cthuhu.