Monsterpunk is a game that draws heavily on Strike! mechanics-wise, and the Shin Megami Tensei series of video games for setting. In short, the players are generally human-monster hybrids in a world conquered by monsters, though the option exists to play a pure human who instead relies on magic or technology.
It's still under development, but I believe you can download the beta version from the Kickstarter page for free.
A post-apocalyptic RPG of humans, monsters and humans becoming monsters.
www.kickstarter.com
If you're looking for something more traditional, there's The King of Dungeons which just came out recently. The mechanics draw upon 13th Age, while the setting is one of professional adventurers.
Lastly, a really interesting game is The Dawnline. It has the least direct correlation to 4e IMO, but you can definitely see the similarity in design philosophy. Combat looks to be quite tactical and is based around infliction and removal of conditions.
The setting is one of nomadic tribes. The sun is perpetually rising, and those who are embraced by the light are never seen again. On the other side, in the darkness, dwell monstrosities. The tribes must continually travel in the band of twilight.
The characters are vampires, of which there are a number of quite diverse bloodlines, who are the defenders of the tribe. However, the vampires rely on the tribe not only for blood, but also to preserve what little vestiges of humanity they still possess.
One of the interesting aspects of this system is that there is a town building and management system. Players need to maintain the morale, resources, and travel distance of the tribe or it will fall apart. The building aspects have numerous options which can empower the characters or aid in management of the tribe.