What I want is probably different from what should be. But I am selfish.
Since it would be a 4th "core" book, I'd feel weird if it were a purely DM facing book. I'm not sure it would work, but I'd like to see a book split into some player facing content and some DM facing content.
It would be some options for players (classes, subclasses, optional equipment, some tips/strategies, optional magic systems or psionics) and some for DM (more tips, monster building rules, more campaign worlds and options, other optional rules and advice).
Boring, but that's what I would want as a fourth core