I didn't play for about two years during which I finished my undergraduate degree. By then I was so antsy that even though it was tough, I squeezed in games during grad school.
I was afraid that when I moved here after graduation and went to work that it would be hard to find a gaming group, but it turned out that several of my co-workers were avid roleplayers, and so things took off right away.
I've gone through a couple of other brief (1-3 month) stints without a game, but always while looking for one or recovering from a "game collapse".