Goblinoids are regarded as pests. The default starting kingdom has a "kill-on-sight" policy.
Human demonic cultists, particularly those living out in the Wastes, often undertake hideous rituals which physically transform them into monstrous humanoids (like Gnolls). Yuan-ti also fall into this category, though their demonic cultism is so old and entrenched that they're nearly a separate race.
The Valaryan Republic is largely human, but practices slavery and does not respect monarchy, and thus sometimes comes into conflict with the default kingdom.
The Libertine Federation of Free Islands is largely human, but harbors pirates and resists colonization & religious conversion, and thus sometimes comes into conflict with the default kingdom.
The Thurn (albino cave elves with a spider fetish) are virtually unknown on this world, but they seek to enslave the humans who live on various other worlds.
Demons, Devils and Yugoloths are an ever-present threat.
An army of skinless dead has attacked many nations around the Great Sea, striking the coast or far inland, and then moving on. Their goal is unknown. In their wake comes a hideous assortment of extraplanar scavengers.
The political activity of the Dragons has increased, and their minions are growing more active in all nations. This may be a prelude to more direct action.
There are fey who blame the recent ecological disaster on humanity, and will seek to eradicate further threat from this obnoxious upstart race just as soon as they recover.
Strange bipedal beings have constructed a hive-city far to the south. Some appear human on the outside, but when you cut them open, their organs are transparent, or are actually agglomerations of blind worms, or evaporate into smoke when they touch air. They are unreasoning, they possess powerful sorcery, and they twist natural creatures into hideous aberrations. The Kaorti will become more of a threat the longer they are left alone.
The Efreeti are not particularly friendly, and neither are the Vampire Lords of the far East.
Er... my PCs are in trouble, aren't they?
Cheers, -- N