I thought so, but I did not want to presume.I fear that getting into it in detail would probably call the moderators down on me, but simply;
D&D and games derived from it is ultimately tell the story about going into someone's home, using violence, and taking their stuff. That's also the story of "how the west was won." If you want to tell a culturally sensitive story about the wild west or a similar frontier, D&D is not the medium to tell that story in.
The only alternative is to have some sort of "virgin land" frontier that was never inhabited by people before the arrival of the players, which significantly limits gameplay.
You can do the wild frontier without the colonialism. Just don't put "savages" there. Done.