Yeah, I always figured the clans would work well as classes. Maybe like a D20 Modern class, with Feats every odd level and Talents every even level. But instead of Talents, you get the Disciplines.
So when you get a Talent, you can use it to get, say, "Cloak of Shadows", from Obfuscation. Then when you get your next Talent, you can either get "Unseen Presence", which is the next Obfuscation power on the list, or the first power on the list of another Discipline. Say "Obfuscate" from under Obtenebration.
As for race, make a template for each Vampire Clan, which gives you all the abilities shared by every member of that clan, and allowing for that Vampire to start off with a couple of Discipline abilities right away.