It will effect in the long run somewhat. I have maybe several hundered figs, but lately we have moved to D20Pro for mapping and the virtual minis have taken over from the battle mat and WOTC or metal minis. My ultimate goal is to do the projector and mini combination for the best overall table top experience, however a projector is out of my price range right now. So consequently we have been using virtual minis with my HD 23" computer monitior (I paid $200 for 3 months ago). We can zoom in as needed (I have a player with vision problems), and the speed of mapping is greatly increased (no drawing out the map time, etc.) Best of all the graphics can be found anywhere on the net and utilizzed in the software. I can use the actual artwork for a monster and turn it into a mini on the screen in a very short time frame. No substiutions for creatures! What you see is what you fight!
While I tried to do both at the same time, using the D20Pro to map and reflect the setup on the battle mat, it got too time consuming and players would forget to move their mini to match the computer screen, and vice versa for me as DM. In the end the computer won out. I have not used my minis now for the last four sessions and don't anticpate I will be any time soon.
That said I still will miss the mini line. I hope that another company (Paizo I am looking at you) may consider taking up the pre-painted market (metal or plastic). I hope for plastic since you can't break them unless you really try, but I know the cost to produce them is getting worse all the time. I Know other companies will fill the void somewhat with metal, but I don't have time to paint that often, even though I am a amateur artist. I would prefer to put brush to canvas not metal with the time I have, which is not much with a wife and three young children.
hopefully the future will see multi-packs with themed figs like goblinoids, aberations, elementals, outsiders, etc.
Cheers!
Hippy