I would like to know if we are going to see only one alien specie, or if we are going to see different factions.
If there will be an Exodus d20 then this should appear in the VTT of D&DB, and maybe in the future the option to load virtual miniatures based in other sci-fi franchises. You can guess players will want to create their homemade "collabs" from videogames(Starcraft, Destiny, Halo, Overwatch) or sci-fi teleseries (Stargate, Andromeda, Farscape, Babylon 5...).
My thoughts:
The system of this future Exodus TTRPG could be "recycled" for other sci-fi licences. This time we should say goodbye to a new Star Wars d20 (and Hasbro should untrust Netflix after the incident of Rebel Moon RPG) but other options could remain. Or even to create mash-up version of other sci-fi TTRPGs (Dune, Fanding Suns, Warhammer 40.000. Mass Effect).
This Exodus d20 will not can to be compatible with D&D because the power balance is totally different. If the Exodus TTRPG is more focused into the lore/background/metaplot/fluff than the crunch part, then players will use that creative freedom to add their most bizarre ideas. Who will need playtest for the power balance to avoid OP PCs or monsters?
If Exodus PCs can enjoy "superpowers" then we can bet we are going to see lots of "clones" of Ashoka Kano.
After buying my Eclipse Phase RPG, I miss the "transhuman technology" of mind-upload and digital inmortality in the rest of sci-fi TTRPGs. Of course this shouldn't hard to be fixed in sci-fi RPGs with a lot level of crunch (Paizo's Starfinder is a different thing).
* My fear is players adding homebred version of alien species based in ufology from our real life.