Same goes for Ptolus in 3e. Monte Cook wanted to create a city setting that was everything D&D turned up to 11, and he used it as his play test campaign.It's not an official setting, but I think @SlyFlourish 's City of Arches is built on the rules conceits of the 5e ecosystem.
From its design it is crafted so any combination of nature, nurture and heroic path are possible -- no matter how weird and offbeat they feel to us old timers.
The enemies are not purely evil, but shades of grey. The minimization of alignment in 5e is reflected in this choice.
There are dungeons, but there's also a stronger sense of urban play.