I went with I'd give it a go, but I doubt it.
I could easily play in a monster sort of game, going with an orc or goblin or the like, but that's presuming there were actually humans and the like in it, just not PC's.
However, a campaign setting that utterly lacked them? It'd be a hard sell. The moment "No humans" cropped up, I'd raise my brow and wonder just what to expect.
Any DM who tossed out a line like, "I find humans boring," would likely earn my ire, and give me a poor impression to the game. I'd be expecting a game where being neat and kewl would be of the utmost of importance, which would really only keep me interested for a one-shot. After that, the novelty would wear off. Bigger or different isn't always better, and I think being different for differences sake often doesn't work out well. Some familiarity is necessary.