Look at my sig. Do you honestly think I wouldn't use the Scarred Lands SEVERAL times in a row even if it's with different PCs and locales? Hell might even be in different time frames!
With this being my 30th anniversary gaming I'm really excited to run something special. My preference would be Star Trek, a universe I never get tired of exploring (and adding too ) or a return to my classic homebrew D&D world. So if the question is, more clearly worded, "Would you use the same setting as your using now for your next campaign?", then my answer is no.