I have to say that this is not enterily true. The world of the Nentir Vale assumes there is no Superpower and that the Armaggedon is coming. Unlike generic fantasy worlds, the Nentir Vale is a world in a pretty dark age.
To elaborate, the generic settings of D&D assume that humans are the dominant race in the world, that there is the Kingdom that protects the world (think of FR's Cormyr or the Lords' Alliance) and that the evil forces are keep at bay by the good guys (Elminster, Dritzz and other super powered npc), and that the gods keep at bay the supernatural Evils mortals can only fathom.
In the Nentir Vale, the Kingdom and the super powered NPCs all got wiped out in the last war, and while the evil forces didn't fared well either, they survived and are mustering forces to wipe out what remains of civilization. As a result, humans are not the dominant race. In fact, there is no dominant race, just scattered survivors that band together to survive the next orc horde.
Heck, even the gods got wiped out by the elder evils, and the current pantheon is composed of just the survivors of the Dawn War. You can see evil gods going along with good gods, because is the only way they can survive the next attack from their enemies. So, this is way different to the Realms, where Bane, Shar and Lolth can plot to conquer the world without fear of reprisal.
My point is that this setting is different to and have its unique hooks, when compared with the more vanilla depictions of the more common D&D settings, like Greyhawk or the Realms.
But, I agree with your opinion about the odds of this setting being in the next product. And those of the other settings, as well.