Some tips:
Giant radscorpions are B*****DS!! I hate 'em ugh, only deathclaws are worse.
but, I found soetehing out..they seem very vulnerable to mines!
I don't know if it's because most of their body is over a mine (so more damage) or a deliberate weakness, but 3 or 4 fragmines, or a single bottlecap mine blows the swine flying through the air, muhaha!!!
put them down in a pattern, so one blast won't set off ALL the mines in the larger pattern.
So, for giant radscorpions,what I like doing is making a cross, with 3 or 4 fragmines in each position.
The Railway Gun is a hoot! and note it is indeed RAILWAY, not rail, gun

Awesome fun sneak critting, cause it looks so damned fun as the spike goes through them.
Note, when sneaking unless you have a perk (can't recall name) or veyr high skill, you better go to WALK mode, as the defualt RUN mode adds a penalty to your Stealth skill.
To earn EXPLODING PANTS, what you do is sneak up to an enemy pick pocket them, and give them a frag grenade, which becomes a LIVE frag grenade...BOOM!
hahahaha!! hysterical. needs high sneak skill or use a Stealth Boy.
dart gun schematic can be bought from a vendor in Tenpenny tower. one of the best weapons in the game. low damage, but, it cripples the enemy's legs automatically and does damage over time, so, if a monster is a meleer or you wish to pul it through mines, it's ideal.
Watch when shooting vehicles, as they may epxlode, causes a nuclear epxlosion, which can of course...be very useful....
Companions (not Dogmeat) can carry stuff for you, and Charon can use rifle type weapons, so I give him a Chinese assault rifle.
Shooting grenades in enemies' hands sets them off...
If your explosives skill is high enough you cna not only disarm "grenade necklace" tripwires, you can take the grenades as well!
The "Fatman" mini nuke launcher
lobs the nukes in an ARC, so watch that, takes practice or VAT to hit targets.
Note, that if you are in sneak mode, and an enemy goes over a mine of yours...it counts as a sneak attack!! much evil fun!
There more often more than one way of doign things, but, there's a sort of open cast mine area with raiders...
[sblock="Sneakiness"]
Instead of jsut shooting them you can do this:
they have a mutant behemoth inside an electrified enclosure. if you shoot the generator with a sniper weapon or scoped 44, from afar, the generator blows up, the electricity goes off and the mutant behemoth come sout and kicks most of their asses, haha!!!
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Do NOT get the perks for extra xp or levels, you are capped to lvl 20, so you'll get there anyway and lose out on perk slots for useful things. Wish I had know that!!
Repair is a VITAL skill. repair one item with a same, or similar item (Lincoln RIfle is repaired by a standard Hunting rifle for example). Good condition weapons are hugely more effective.
Do NOT rush through the game, epxlore epxlore explore! don't go through the main quest arc, exclusively, there's tons to see, and do out there!
Quesiton though: laser weapons have sucky damage, what's the advantage of them, beyond setting gas off? (igniting gas is fun, lol).