Voted: Positive, then negative.
Reason #1: GSL.
Reason #2: 4E is more narrativist than simulationist. There are systems which I prefer for narrativist approach.
Reason #3: 4E treatment of existing settings, lacking support for transition to the new system.
Warning: Rant ahead, not entirely on topic.
There are very good alternatives to 4E out there. For 3.5 fans there is 3.5 in numerous variations. For fans of simplified and unified resolution system, there are True20, M&M, C&C. If you want over the top fantasy, try Exalted.
I am against stifling creativity or monopolizing the market. I prefer straight competition instead of strangling publishers. So GSL was and is still a final dealbreaker for me.
Finally, to me book burning for _any_ reason is wrong (yes, I am a "bookophile"). Nothing changed this opinion of mine and this is the ultimate reason I am unlikely to support anything by WotC... anyone may point that it was both within d20 STL license and GSL license and therefore a legal thing. Still, I feel really bad about that, and to me it still constitutes abuse of legal system.
There should be at least terms for graceful expiration and possible mandatory release to public domain of licensed content instead of voiding right to exist.
Regards,
Ruemere