And in fact, while you can certainly call Golarion a "kitchen sink" setting, I think that's a gross oversimplification. One of the big driving goals for us with Golarion was not to make a "generic, kitchen sink" setting, but one that embraced a wide range of settings. You can run a classic Eurocentric game, a horror game, a science-fiction meets fantasy game, a "The undead are the ruling class" game, an Egyptian themed game, an Arabian Nights game, a pirate-themed game, a viking-themed game, and so on and so on.
And we DO periodically move beyond that as well. The Dragon Empires where we went for more Asian-themed stories, for example. And Distant Worlds touched upon the idea of playing on other, alien planets. All of these are part of the same campaign setting, though, and that allows us to focus on just one setting without falling prey to the setting-fracturing that helped kill TSR.