Seems to me that it depends on each individual game. There are scenes in fiction I could see playing out in a similar manner in a D&D game.
An assassin catching their target using the jakes.
Sneaking into a castle through the jakes.
Getting into a walled city through the sewer.
Identifying scat in the wilderness.
Tyrion shooting his father with a crossbow while on the toilet. (Game of Thrones)
Billy the Kid (Emilio Estevez) serving a warrant in an outhouse...by shooting him while he's relieving himself. (Young Guns)
Buckshot Roberts (Brian Keith) taking refuge in an outhouse during a gunfight, then taking the opportunity for a Constitutional... (also Young Guns)
As long as it's a
potty point plot point, seems to me it could have a major impact.