What is distinctive about Forgotten Realms to you besides the powerful NPCs? What am I supposed to like enough to run a FRealms campaign when I don't like Elminster, the Simbul, etc.?
I don't know. I have no idea what you like. I gave a pretty detailed example from my current campaign a few pages ago that explained what I chose to use and what I ignored and why. That post went largely ignored, so I'm not going to go into all that detail again.
What's cool about any setting other than the high level NPCs? I'm sure that the FR has stuff that you'd dig, just like Krynn may, or Oerth, or Mystara. When we're talking about these "kitchen sink/Tolkienesque" settings, it boils down to a matter of preference based on which setting has the most elements that appeal to an individual.
I personally like the idea of separate cuty states loosely affiliated for common interest, but separated by distance and wild territory. I like the Empire of Shade. I like Sembia, a nation of roguish, self serving merchant houses. I like the untamed jungles of Chult.
None of these things is necessarily uniquely original or specific to the FR. But neither are the elements of the other settibga I mentioned. They're all just as generic or easily moved to another setting as any of the FR elements.
But regardless if setting, if I as the DM choose to have NPCs swoop in and save the day, or even just assist the PCs, and my players fon't dig that, then I have erred as a DM and shouldn't blame it on the setting.