Probably, but maybe not. So far, the changes aren't as fundamental as the 3E/3.5 shift, which changed how weapons worked, for instance. (A change to any given class or how you categorize spells is a compartmentalized change that only affects a limited subsystem.)
The best point of comparison at this point is probably Monsters of the Multiverse. There was a lot of howling about the book's changes. Are DMs still using Mordenkainen's Book of Foes and Volo's Guide to Monsters? I bet there are some DMs still using the older books, especially for spellcaster NPCs.