I like settings as a DM and for just enjoyment of reading settings. But as a player, which is what I am the past several years, yeah I don't care a lot and none of our group does either. We're in Waterdeep: Mad Mage in one campaign, and it could be any city above for all we'd care. We're in Tomb of Annihilation in the other, and we love Chult and the setting...but it could have been any jungle and any political background for that area and we wouldn't have cared much. The fact these are both Forgotten Realms is meaningless to us. The fact there are other continents and cities and such in this setting is meaningless to us. The environment matters but a lot of the larger setting does not.