I'm not the most devout Fallout fan.. I've only played the 3D era of the games, and despite putting lots of hours into multiple playthroughs of 3, NV, and 4, I never finished any of them. With that said I think that kind of makes me the perfect audience for the show. I get tickled by all the easter eggs and fan service, but also don't get bitter about changes or failure to adhere to lore.
I really enjoyed season 1, and so far found episode S2E1 alright. Good enough for a season opener. A lot happened, and it was a little rough to watch with my GF, who's never played any of the games, and didn't watch the first season with me. So trying to explain things from both sides to her, and remember what all happened in season 1 and what I know of the game lore was tough.
I like Lucy as a protagonist because she's exactly the kind of character I always try to play in Fallout, and similar games, trying to Charisma my way out of situations I'm not even remotely Charismatic enough for.
I think I'm most interested in seeing how the 3 Vaults story plays out.