There can be multiple portfolios, but they'd generally be associated somehow. Murder, death and entropy for example. You wouldn't see entropy and fertility under the same god.
Well, what about something like fertility and death? Dead things are essential for making nutritious new soil. Similarly the creation/destruction duo is a pretty common one even in IRL religions because by creating something, you usually had to break down or consume materials, and we often create other new things by destroying something that already exists. (Or things like
kintsukuroi where you repair something that was broken, and in so doing, make it beautiful.)
Likewise, IRL deities have included stuff like Aphrodite Areia, "Warlike Aphrodite," who was the goddess of both beauty/love(/fertility) and
war, descending from Ishtar, goddess of beauty, sex, war, political power, and divine law.
Historical gods tended to be pretty complex things, sometimes even outright contradictory. Dionysus is another example, often being both the anti-establishment madness-bringer
and the pro-establishement conquering king. Hephaestus/Vulcan would be an example of the creation-and-destruction god, being associated with Mt. Etna, weapons (e.g. Zeus's thunderbolts), and destruction, but also creative arts, industry, and defense.