Heck no! I'll probably play both. More 5E locally (the game store prefers d&d 5e) and will play pf2 where I can. Probably conventions like PAX or Megacon. I'm still on the fence about running a game of pf2. I have players that much preferred 5e over PF1 so not sure if they will be willing to try the plaguestone adventure but if they want to try it I will run it.