I had a player who was particularly reckless. I realised he was meta gaming: daring me to kill his character, thinking I wouldn't. If your players are effectively pushing you around, then stand firm and let the story happen. (Maybe add in a bit where there mistake becomes revealed just before the inescapable final battle).
Look. If you flex the world around the players too much, you might as well go systemless and allow everyone to make up whatever they want to happen. If the clue was massive and fairly well signposted, then be apologetic, wreak havoc, leave some survivors, and write a followup adventure about finding a skilled team and putting the bigbad down. A REVENGE TALE.
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