Best Classes by race

[DracoSuave]

Tieflings make surprisingly good Cha-ladins. The bonus to charisma is tight, and Infernal Wrath combos -really- wall with getting hit, something a defender likes to do.

 

[Mengu]

I don't know about best, but my favorites are:

Dwarf Fighter
Dragonborn Warlord
Eladrin Wizard
Elf Ranger
Half-elf Paladin
Halfling Rogue
Human Wizard
Tiefling Warlock

Human Fighter and Dwarf Cleric are also among my favorites.

 

[Bluewyrm]

Longtooth Shifter TWF Ranger... Twin Strike plus Shifting ftw
Dragonborn Fighter... Enlarged Dragonbreath + Combat Challenge == up to 25 marked opponents in a single round!

 

[weem]

I'm not a big number cruncher so I'm not the best for answering this one, but I wanted to say that playing a Minotaur Warlord has been a lot of fun