Zeromaru X
Arkhosian scholar and coffee lover
4e's model works PERFECTLY well for something like 'Seven Deadly Sins' style epic conflict where the PCs are literally invoking and being hammered by epic level magic that blasts the land almost on a scale equivalent to nuclear weapons.
All Shonen anime, actually. There are a lot of series where the characters are injured beyond what's physically possible, bleed litters of blood, and are completely fine the next scene. Like Naruto, Saint Seiya, Fist of the North Star, and many others. In these stories, what matters is the narrative, not the realism/verisimilitude. The same can be said of 4e.
As for injuries, I remember I've used the variant injury rules from an Unhearted Arcana article in Dragon 204. Not all of my players enjoyed this, but those who liked the tactical side of 4e really enjoyed the injuries mechanics.