I actively avoid homebrew settings for one particular reason: every single homebrew setting I have been in in the past 10ish years screws with the system to the point of unbalancing it. Don't get me wrong, I don't mind slightly unbalanced homebrew class/PrC (to bump up the power of the fighter slightly or change the flavor of a different class or etc). But gimping a class to the point of unplayable is where I draw the line.
I love paying wizards and wizard is ALWAYS #1 in line for gimping. One homebrew setting (used the FR map, but that was the only way it resembled the FR setting) made all arcane spellcasters unplayable. Every spell you had to roll an ever increasingly difficult concentration check until you horribly failed, suffered major penalties and then it reset itself. Screw that. Give me a published setting with the base system.